Low-molecular-weight rheumatoid factor.
نویسندگان
چکیده
منابع مشابه
Low molecular weight IgM in juvenile chronic arthritis.
Low molecular weight IgM, the monomeric subunit of pentameric IgM, was clearly detected by immunoblotting and filtration chromatographic techniques in six patients with juvenile chronic arthritis and in trace quantities in a further eight of 24 patients studied. This low molecular weight IgM moiety contributed up to 33% of the total circulating IgM and was strongly associated with raised serum ...
متن کاملCirculating and intra-articular immune complexes in rheumatoid arthritis: a comparative study of the C1q binding and monoclonal rheumatoid factor assays.
The C1q binding assay and the nephelometric monoclonal rheumatoid factor assay were able to discriminate 79% and 57% respectively of rheumatoid arthritis (RA) patients from healthy blood donors. In addition these assays could distinguish those patients with active arthritis from those with inactive disease, and the C1q binding assay correlated significantly with other laboratory indices of the ...
متن کاملInteraction of the Rheumatoid Factor with Antigen-antibody Complexes and Aggregated Gamma Globulin
The effect of highly purified rheumatoid factor on the precipitin reactions of various antigen-antibody systems was determined. The amount of nitrogen precipitated was increased over a broad range when the factor was added to ovalbumin, human albumin, or human gamma globulin, and the corresponding rabbit antibodies. In the zone of antigen excess, soluble antigen-antibody complexes were precipit...
متن کاملQuantitation and evaluation of low molecular weight IgM in rheumatoid arthritis.
Laser nephelometric estimation of IgM in the eluate fractions following Sepharose 6B chromatography has enabled the calculation of the proportion of low molecular weight IgM (7S IgM) in normal and pathological sera. This figure has then been used to determine the absolute amount of 7S IgM. Twenty-seven of 36 (75%) patients with rheumatoid arthritis had 7S IgM with a mean value of 17 mg/100 ml (...
متن کاملStudies on the isolation of rheumatoid factor.
The need for the isolation of rheumatoid factor in a high state of purity and in sufficient quantity for antiserum production has led to an appraisal of the various purification methods available. Ziff, Brown, Lospalluto, Badin, and McEwen (1956) demonstrated that the sensitized sheep cell agglutinating activity of rheumatoid serum was precipitated in the euglobulin fraction, and Svartz and Sch...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 42 شماره
صفحات -
تاریخ انتشار 1963