Impact of hepatitis B virus carrier serostatus on neonatal outcomes after IVF-ET.

An increasing number of infertile, hepatitis B virus-infected individuals have opted for assisted reproductive technology. However, the impact of the hepatitis B virus carrier serostatus on neonatal outcomes has not been evaluated. Data from 504 patients who delivered singletons were analyzed. In females, hepatitis B surface antigen, hepatitis B e antigen, and antibody to hepatitis core antigen seropositivity significantly decreased the gestational age at delivery. In contrast, the male hepatitis B virus serostatus did not affect the gestational age at delivery. Multiple linear regression analysis showed that maternal weight, gestational age at delivery, and infant gender were significantly related to birth weight. The present retrospective study showed that in females, hepatitis B surface antigen, hepatitis B e antigen, and antibody to hepatitis core antigen seropositivity was significantly associated with the gestational age at delivery after in vitro fertilization-embryo transfer (IVF-ET).