Use of the calcium agonist BAY K 8644 for in vitro diagnosis of susceptibility to malignant hyperthermia.

نویسندگان

  • P J Adnet
  • R M Krivosic-Horber
  • G Haudecoeur
  • M M Adamantidis
  • G H Reyford
  • M Imbenotte
  • C Cordonnier
چکیده

We have studied the effects of the calcium agonist BAY K 8644 on the in vitro halothane test in 10 malignant hyperthermia-susceptible (MHS), 12 MH "equivocal" to halothane (MHEh), 30 MH non-susceptible (MHN) and 10 control patients. BAY K 8644 potentiated the halothane-induced contracture in muscle strips from both MHS and MHEh patients. The drug produced a more obvious difference in contracture responses between the MHEh group compared with the MHN and control groups.

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عنوان ژورنال:
  • British journal of anaesthesia

دوره 65 6  شماره 

صفحات  -

تاریخ انتشار 1990