Late Breaking Poster Abstract Title: Unmet needs of Thai cancer survivors: implications for developing support care services. Author first name: Pongpak Author last name: Pittayapan City: Bangkok Country: Thailand

Title: Unmet needs of Thai cancer survivors: implications for developing support care services. Author first name: Pongpak Author last name: Pittayapan City: Bangkok Country: Thailand Institution: Department of Nursing, Siriraj Hospital, Faculty of Medicine, Mahidol University Background: Thailand is one of the country in Asia-Pacific region joined an international servicemapping study of Survivorship care for patients with cancer after Treatment completion (STEP Study) which developed project by Queensland university, Australia. A supportive needs assessment is an essential component of any cancer care program. There is no research evidence regarding the supportive care needs in Thai cancer patients. Methods: A cross-sectional survey was carried out in a Cancer center, University Hospital, Bangkok, Thailand. A total of 160 cancer patients completed the validate scales (Cancer Survivors Unmet Needs scale-CaSUN), physical-symptom concerns (Cancer Survivors Survey of Needs-CSSN subscale) and a single-item measure of global quality of life perception (QOL). Descriptive statistics were used for data analysis. Results: One-quarter of the patients reported poor QOL. Unmet needs of moderate/strong level were particularly high in all aspects assessed, particularly in the area of existential survivorship (psychosocial care) and receiving comprehensive cancer care. Conclusion: Thai cancer patients experience many unmet needs and there is an urgent need for establishing additional survival ship care plan for cancer patients after the end of first line treatments. The results from this study indicate that it is important to develop supportive care services to improve the quality of life in Thai cancer survivor. Abstract Title: A systematic review of exercise and psychosocial rehabilitation interventions to improve health-related outcomes in patients with bladder cancer undergoing radical cystectomyTitle: A systematic review of exercise and psychosocial rehabilitation interventions to improve health-related outcomes in patients with bladder cancer undergoing radical cystectomy Author first name: Elke Author last name: Rammant City: Ghent Country: Belgium Institution: Ghent University Background: Patients with bladder cancer (BC) undergoing radical cystectomy (RC) experience physical and psychosocial side effects of cancer diagnosis and treatment impacting their healthrelated quality of life (HRQoL). Rehabilitation interventions such as exercise and psychosocial support improve patient reported outcomes (PROs) (e.g. HRQol, fatigue, distress) and physical fitness in other types of cancer patients. Unfortunately, evidence is lacking for rehabilitation interventions in BC patients undergoing RC. This systematic review aims to assess the impact of and the adherence to preand postoperative exercise and psychosocial rehabilitation interventions on PROs and physical fitness in patients with BC eligible for RC. Methods: Randomized controlled trials (RCT) and non-randomized studies (NRS) assessing the effects of exercise and psychosocial rehabilitation interventions in BC patients undergoing RC were eligible. The primary outcome measures were patient reported outcomes (e.g. Qol, fatigue, pain) and physical fitness. Studies were identified independently by two authors by searching the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, Web of Science and the Physiotherapy Evidence Database. Risk of bias was assessed using the Cochrane Collaboration tool and the Newcastle-Ottawa Scale. In addition, sample size was evaluated as a quality indicator of precision. Results: Five RCTs and one NRS were identified. Quality assessment showed most shortcomings with sample sizes (including high dropout rates), performance and detection bias. Positive significant effects of exercise interventions were found for physical fitness, some HRQoL domains, personal activities in daily living and muscle strength. Psychosocial interventions showed positive significant effects for anxiety, fatigue, depression, HRQoL and posttraumatic growth. Conclusion: This review showed that rehabilitation interventions could improve several PROs, physical fitness and muscle strength in BC patients undergoing RC. However, exercise and psychosocial research remains an understudied area in the field of BC so more well-designed studies are needed. Abstract Title: Body image mediates the effect of cancer-related stigmatization on depression: a new target for interventionTitle: Body image mediates the effect of cancer-related stigmatization on depression: a new target for intervention Author first name: Peter Author last name: Esser City: Leipzig Country: Germany Institution: Abteilung für Medizinische Psychologie und Medizinische Soziologie, Universitätsklinikum Leipzig Background: Since cancer-related stigmatization is prevalent but difficult to change, research on its impact on psychological burden and mechanisms buffering this effect is needed. Therefore, we investigated the effect of stigmatization on depressive symptomatology and whether body image mediates this relationship. Methods: This bi-centric study assessed patients of four major tumor entities. We measured stigmatization, depressive symptomatology and body image with the four-dimensional SIS-D, the PHQ-9 and the two-dimensional FKB-20, respectively. We applied multiple mediator analyses. In detail, we calculated the total effect of stigmatization on depressive symptomatology and the indirect effects exerted via the two body image scales rejecting body evaluation and vital body dynamics. Results: Among the 858 cancer patients recruited (breast: n=297; prostate: n=268; colorectal: n=168; lung: n=125), stigmatization showed robust total effects on depressive symptomatology across all stigma dimensions (all ptotal sample<.001). Except for lung cancer patients, this result could be replicated for each cancer group. Body image was shown to mediate the effect across all samples (γtotal sample = .04, 95 %CI: 0.03 – 0.06). Among the total sample and colon cancer patients, the mediating effect of rejecting body evaluation was significantly larger than the effect of vital body dynamics (dtotal sample = .02, 95 %-CI: 0.01 – 0.04). Conclusion: Perceived stigmatization is an important and generalizable risk factor for depressive symptomatology among cancer patients. Body image was shown to be a buffering variable. Apart from interventions addressing stigmatization, body image could be targeted in order to reduce the psychological burden in stigmatized patients. Abstract Title: W-Decide: a guided internetand mobile-based self-help intervention for adult cancer patients with depression – design and results of a randomized controlled feasibility trialTitle: W-Decide: a guided internetand mobile-based self-help intervention for adult cancer patients with depression – design and results of a randomized controlled feasibility trial Author first name: Natalie Author last name: Bauereiß City: Ulm Country: Germany Institution: Department of Clinical Psychology and Psychotherapy, University of Ulm Background:Depression is common in cancer populations and associated with worsened patient outcomes. Barriers to mental health care are still high for cancer patients, including stigmatization or limited mobility. Internetand mobile-based interventions are an innovative approach to overcoming these barriers. The present trial aims at evaluating the feasibility and potential effectiveness of “WDecide”, a guided internetand mobile-based self-help intervention for adult cancer patients with depression. Methods:A parallel group randomized controlled feasibility trial will be conducted. Recruitment is currently in progress and will last until August 2017. Participants will be randomly assigned to either the intervention group (n=30) or a wait-list control group (WLC) (n=30). W-Decide is based on cognitive behavioral therapy and consists of seven weekly guided lessons, up to six optional lessons on various topics (e.g. sleep) and one booster lesson. Participants in the WLC will get access to the unguided intervention after the final assessment. All participants will have unrestricted access to care-as-usual. Feasibility of recruitment, intervention and safety procedures will be the primary outcome. Secondary outcomes will be assessed at baseline and post-intervention and include depression, anxiety, quality of life, fear of progression and cancer-related fatigue. Intervention effects will be analysed based on an intention-to-treat approach. Results:Rationale, design and preliminary results of the study will be presented at the congress. Conclusion:This study contributes to improving and facilitating mental health care for cancer patients. Findings regarding feasibility and patient outcomes will inform decisions on the progression to a future definitive randomized controlled trial. Abstract Title: Meta-analysis of Psychosocial Treatment Effects on Cancer Survival: Sources of HeterogeneityTitle: Meta-analysis of Psychosocial Treatment Effects on Cancer Survival: Sources of Heterogeneity Authors: Špela Križanec, Helena Kraemer, Booil Jo, Mona Ershadi, Eric Neri, Bita Nouriani and David Spiegel Author first name: Špela Author last name: Križanec City: Ljubljana Country: Slovenia Institution: University of Ljubljana, Medical Faculty, Department of Family, Poljanski nasip 58, 1000 Ljubljana, Slovenia Background: Consistent associations have been reported between psychosocial variables and cancer progression/mortality and this has served as the foundation for studies researching the effect of psychosocial interventions on survival. Currently, there are seven meta-analyses that address this question and they reach different conclusions. One reason for inconsistent findings may be the methods by which previous meta-analyses were conducted. The aim is of this study is to evaluate the effect of psychosocial interventions on survival and to explore reasons for heterogeneity, using hazard ratios (HR). Methods: Databases (September-December 2015) were searched to identify valid randomized controlled trials that compared psychosocial intervention with usual care. Hazard ratios and their confidence intervals were pooled to estimate the strength of the treatment effect on survival time and z-tests were performed to assess possible heterogeneity of effect sizes associated with different patient and treatment characteristics. Results: Twelve trials were included (involving 2,471 patients) of which four were cognitivebehavioral (CBT), three supportive-expressive (SEGT), three psychoeducational, and two supportive interventions. The overall survival effect favored treatment groups, with a HR of 0.74 (95% Cl [0.650.83], p=0.001, I=65%). An effect size favoring treatment group survival was observed in studies sampling patients with lower social support (NNT=5.4 versus NNT=15.9), at early cancer stage during CBT treatment (NNT=0.7 versus NNT=-29.0), and in patients older than 50 years (NNT=4.9 versus NNT=-20.4). Conclusion: Psychosocial interventions may have an important effect on survival. Although subgroup results are exploratory, they provide promising directions for future studies and crucial information for clinical decision-making. Abstract Title: Alexithymia in breast cancer patients and their sisters in SeoulTitle: Alexithymia in breast cancer patients and their sisters in Seoul Author first name: Shubha Author last name: Maudgal City: Mumbai Country: India Institution: Cancer Patients Aid Association Background: The purpose of this study was to examine the levels of alexithymia in breast cancer patients, their sisters and healthy controls in South Korea. Methods: The Korean version of the Alexithymia Questionnaire was used to compare the groups. The study group consisted of 98 breast cancer patients, 50 sisters and 43 healthy controls. Results: The highest level of alexithymia was reported in patients, followed by their siblings. Healthy controls reported the lowest level of alexithymia. Difficulty in describing feeling scores has shown significant negative correlation with age and marital status among women with breast cancer. Women 51 years and above and married women have scored lower than those below 50 years aged women and those who are single, in a live in relationship, widowed or divorced. No such significant correlation was observed among siblings and control group. The intensity of cancer was a significant predictor of the alexithymia score. Patients with T4 stage disease reported the highest levels of alexithymia. No significant differences were found among patients with lower staging. Conclusion: Not only breast cancer patients, but also their sisters show significantly more alexithymia than their healthy counterparts. Counselors can use the alexithymia questionnaire to identify person s who require support to prevent or reduce psychological problems in patients and siblings. Abstract Title: The Vaccine Hesitancy Scale: Psychometric properties and validationTitle: The Vaccine Hesitancy Scale: Psychometric properties and validation Author first name: Gilla Author last name: Shapiro City: Montreal Country: Canada Institution: McGill University Background: As some cancers can be prevented through vaccination, understanding vaccine hesitancy is critical. The SAGE Working Group on Vaccine Hesitancy developed the Vaccine Hesitancy Scale (VHS); however, this scale has not yet been psychometrically evaluated. Methods: Using a cross-sectional design, we collected self-reported survey data from a large national sample of Canadian parents from August to September 2016. An online questionnaire was completed in English or French. In addition to the VHS, measures included socio-demographics items, vaccine attitudes, parents’ human papillomavirus (HPV) vaccine decision-making stage, vaccine receipt and refusal. Results: A total of 3779 Canadian parents completed the survey in English (74.1%) or French (25.9%). Factor analysis of the VHS revealed that a two-factor structure best explained the data, consisting of ‘lack of confidence’ and ‘risks’. A relationship was found between the scales and vaccine attitudes. ANOVA found significant differences in the VHS sub-scales by parents’ vaccine decision making stage. Independent samples t-tests found that the VHS sub-scales were associated with HPV vaccine receipt, HPV vaccine refusal, and refusing another vaccine. Socio-demographic differences in VHS sub-scales were found; however, effect sizes were small. Conclusion: The VHS was found to have construct and criterion validity in identifying vaccine hesitant parents. A limitation of the VHS was few items that loaded on the ‘risks’ component and a lack of positively and negatively worded items for both components. Based on these results, we suggest modifying the wording of some items and adding items on risk perceptions. Abstract Title: Preserving Sexual Function after Bone Marrow TransplantTitle: Preserving Sexual Function after Bone Marrow Transplant Author first name: Wendy Author last name: Vanselow City : Melbourne Country: Australia Institution: Royal Women’s Hospital 20 Flemington Rd Parkville Victoria