Restriction polymorphism FABGL/BbvI in herd of sows derived from crossing Polish Large White x Polish Landrace breeds

The FABGL gene encodes a nicotinamide adenine dinucleotide (NAD)-dependent 17β-hydroxysteroid dehydrogenase (17b-HSD) which is responsible mainly for immune response. It can also regulate the concentration of biologically active estrogens and androgens. It is appear as oxidative enzyme that inactivates estradiol, testosterone, and dihydrotestosterone as well as reductive enzyme by synthesis of estradiol from estrone. Investigations showed that FABGL gene is expressed within the ovaries and testes. Different variants of this gene may be associated with reproduction traits in pigs. The aim of this study was to determine polymorphism in the promoter region of FABGL gene as well as examine associations between particular genotypes and reproduction traits in Polish Large White x Polish Landrace sows. Polymorphism in FABGL/BbvI was determined by applying PCR-RFLP and following frequency of alleles were obtained: A 0.45, B 0.55. Statistical analysis showed associations (P≤0.05, P≤0.01) between particular genotypes and some reproduction traits in investigated herd of sows.