In the Search for New Anticancer Drugs, I Antitumor Activity of Various Nitroxyl- and Aziridine-Containing Phosphorus Compounds
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چکیده
Antitumor Activity, Phosphorus Compounds A series of pentavalent phosphorus compounds containing the nitroxyl and/or aziridinyl moieties was evaluated for antitumor activity against P 388 and L 1210 lymphocytic leukemias, and compared to the clinical agent thio-TEPA (1). The compounds with the structures 5-13 were found to be active, with a T/C value greater than 125. The percent ILS was also determined.
منابع مشابه
In the Search for New Anticancer Drugs, II Antitumor Activity, Toxicity and Electron Spin Resonance of Spin Labeled Thio-TEPA Derivatives
The spin labeled analog of Thio-Tepa, l-oxyl-2,2,6,6-tetramethyl-4-piperidylN,N;N',N'-bis (ethylene )-phosphorodiamidothioate (SL-O-TT), which contains a nitroxyl free radical linked by an oxygen bridge to phosphorus, has antitumor properties against P388 murine leukemia (T/C = 242) and a higher therapeutic ratio (5.15) than its parent compound, Thio-TEPA (2.75). The drug is less toxic to P388 ...
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