Metachronous colon cancer risk following surgery for first primary rectal cancer in Lynch syndrome
نویسندگان
چکیده
Background It is known that metachronous colorectal cancer risk for Lynch syndrome patients with primary colon cancer is high and total colectomy is the preferred option [1]. However if the index primary cancer is in the rectum, management advice is complicated by considerations of worsening bowel function or stoma formation. To aid surgical decision-making, we estimated the risk of metachronous colon cancer for Lynch syndrome patients who underwent either anterior resection or abdominoperineal resection for primary rectal cancer.
منابع مشابه
Metachronous colorectal cancer risk for mismatch repair gene mutation carriers – the advantage of more extensive surgery
BACKGROUND Surgical management of colon cancer for patients with Lynch syndrome who carry a mismatch repair (MMR) gene mutation is controversial. The decision to remove more or less of the colon involves the consideration of a relatively high risk of metachronous colorectal cancer (CRC) with the impact of more extensive surgery. OBJECTIVE To estimate and compare the risks of metachronous CRC ...
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