Lactoferrin and Necrotizing Enterocolitis in Preterm Infants
نویسندگان
چکیده
Neonatal necrotizing enterocolitis (NEC) is the most important neonatal problem in nursery which is associated with high neonatal mortality and morbidity. NEC also leads to various long term complications, including short bowel syndrome, systemic infection, eye problems, nutritional deficiency and neurodevelopmental impairments. Lactoferrin (LF) is a component of breast milk and multiple actions that includes antimicrobial, antiviral, anti-fungal, enhance immunity and various other actions. A few studies have been completed and a number of trails are going on for evaluation of efficacy and safety of LF in the prevention of NEC. In future, LF prophylaxis and therapy may have a significant impact in improving clinical outcomes of vulnerable premature infants. This review analyse the role of LF in prevention and reduction severity of NEC in preterm infants, with emphasis on mechanism of action, recent studies and current studies going on all over the world.
منابع مشابه
An update on necrotizing enterocolitis: pathogenesis and preventive strategies
Necrotizing enterocolitis (NEC) is one of the most critical morbidities in preterm infants. The incidence of NEC is 7% in very-low-birth-weight infants, and its mortality is 15 to 30%. Infants who survive NEC have various complications, such as nosocomial infection, malnutrition, growth failure, bronchopulmonary dysplasia, retinopathy of prematurity, and neurodevelopmental delays. The most impo...
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