Early complement components enhance neutralization of Chlamydia trachomatis infectivity by human sera.
نویسندگان
چکیده
Immunoglobulin G in human serum neutralizes chlamydial infectivity in vitro. Complement-intact, C5-depleted, and C8-depleted human serum all have significantly more neutralizing activity than serum heated to inactivate early components of complement. Cobra venom factor, an analog of human C3b, enhances neutralization of antichlamydial immunoglobulin G in the absence of early complement components.
منابع مشابه
Chlamydia trachomatis major outer membrane protein variants escape neutralization by both monoclonal antibodies and human immune sera.
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ورودعنوان ژورنال:
- Infection and immunity
دوره 60 6 شماره
صفحات -
تاریخ انتشار 1992