Alternative RNA processing: determining neuronal phenotype.

نویسندگان

  • M G Rosenfeld
  • S G Amara
  • R M Evans
چکیده

On the basis of an analysis of the human and rat calcitonin genes and of a related gene, alternative RNA processing represents a developmental strategy of the brain to dictate tissue-specific patterns of polypeptide synthesis. This regulation allows the calcitonin gene to generate two messenger RNA's, one encoding the precursor of a novel neuropeptide, referred to as CGRP, which predominates in the brain, and the second encoding the precursor to the hormone calcitonin which predominates in thyroid C cells. The distribution of CGRP in the central and peripheral nervous system and in endocrine and other organ systems suggests potential functions in nociception, ingestive behavior, cardiovascular homeostasis, and mineral metabolism.

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عنوان ژورنال:
  • Science

دوره 225 4668  شماره 

صفحات  -

تاریخ انتشار 1984