Proteolytic regulation of toxin - antitoxin systems by ClpPC in Staphylococcus aureus 1 2
نویسندگان
چکیده
3 GlaxoSmithKline, King of Prussia, PA, 19406 8 9 *Corresponding author: 10 Department of Microbiology & Immunology, Dartmouth Medical School, Hanover, NH 11 03755 12 Phone: (603) 650-1310 Fax: (603) 650-1318 13 Email: [email protected] 14 15 16 17 Running Title: ClpPC degrades S. aureus antitoxins 18 Copyright © 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Bacteriol. doi:10.1128/JB.00233-09 JB Accepts, published online ahead of print on 28 December 2009
منابع مشابه
Proteolytic regulation of toxin-antitoxin systems by ClpPC in Staphylococcus aureus.
Bacterial toxin-antitoxin (TA) systems typically consist of a small, labile antitoxin that inactivates a specific longer-lived toxin. In Escherichia coli, such antitoxins are proteolytically regulated by the ATP-dependent proteases Lon and ClpP. Under normal conditions, antitoxin synthesis is sufficient to replace this loss from proteolysis, and the bacterium remains protected from the toxin. H...
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