Procedures controlling generalized false discovery rate

نویسنده

  • WENGE GUO
چکیده

Procedures controlling error rates measuring at least k false rejections, instead of at least one, can potentially increase the ability of a procedure to detect false null hypotheses in situations where one seeks to control k or more false rejections having tolerated a few of them. The k-FWER, which is the probability of at least k false rejections and generalizes the usual familywise error rate (FWER), is such an error rate that is recently introduced in the literature and procedures controlling it have been proposed. This paper considers an alternative and less conservative notion of error rate, the k-FDR, which is the expected proportion of k or more false rejections among all rejections and generalizes the usual notion of false discovery rate (FDR). Procedures with the k-FDR control dominating the Benjamini-Hochberg stepup FDR procedure and its stepdown analog under independence or positive dependence and the Benjamini-Yekutieli stepup FDR procedure under any form of dependence have been constructed.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Stepdown Procedures Controlling A Generalized False Discovery Rate

Often in practice when a large number of hypotheses are simultaneously tested, one is willing to allow a few false rejections, say at most k−1, for some fixed k > 1. In such a case, the ability of a procedure controlling an error rate measuring at least one false rejection can potentially be improved in terms of its ability to detect false null hypotheses by generalizing this error rate to one ...

متن کامل

Stepup Procedures Controlling Generalized Fwer and Generalized Fdr

In many applications of multiple hypothesis testing where more than one false rejection can be tolerated, procedures controlling error rates measuring at least k false rejections, instead of at least one, for some fixed k ≥ 1 can potentially increase the ability of a procedure to detect false null hypotheses. The k-FWER, a generalized version of the usual familywise error rate (FWER), is such a...

متن کامل

Stepup Procedures Controlling Generalized Fwer and Generalized Fdr1 by Sanat K. Sarkar

In many applications of multiple hypothesis testing where more than one false rejection can be tolerated, procedures controlling error rates measuring at least k false rejections, instead of at least one, for some fixed k ≥ 1 can potentially increase the ability of a procedure to detect false null hypotheses. The k-FWER, a generalized version of the usual familywise error rate (FWER), is such a...

متن کامل

A New Proof of FDR Control Based on Forward Filtration

For multiple testing problems, Benjamini and Hochberg (1995) proposed the false discovery rate (FDR) as an alternative to the family-wise error rate (FWER). Since then, researchers have provided many proofs to control the FDR under different assumptions. Storey et al. (2004) showed that the rejection threshold of a BH step-up procedure is a stopping time with respect to the reverse filtration g...

متن کامل

Resampling-based empirical Bayes multiple testing procedures for controlling generalized tail probability and expected value error rates: focus on the false discovery rate and simulation study.

This article proposes resampling-based empirical Bayes multiple testing procedures for controlling a broad class of Type I error rates, defined as generalized tail probability (gTP) error rates, gTP (q,g) = Pr(g (V(n),S(n)) > q), and generalized expected value (gEV) error rates, gEV (g) = E [g (V(n),S(n))], for arbitrary functions g (V(n),S(n)) of the numbers of false positives V(n) and true po...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2006