Optogenetics-guided Cortical Plasticity Following Forepaw Denervation
نویسندگان
چکیده
N. Li, J. Downey, A. Bar-Shir, A. A. Gilad, P. Walczak, H. Kim, S. E. Joel, J. J. Pekar, N. V. Thakor, and G. Pelled F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, The Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, Cellular Imaging Section, Vascular Biology Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States
منابع مشابه
Denervation of the forepaw induced a rapid and sustained shift in the location of the border between the forepaw and lower jaw representations of adult S1 (reorganization). Coronal slices from the reorganized region were maintained in vitro
Peripheral denervation causes significant changes in the organization of developing or adult primary somatosensory cortex (S1). However, the basic mechanisms that underlie reorganization are not well understood. Most attention has been focused on possible synaptic mechanisms associated with reorganization. However, another important determinant of cortical circuit function is the intrinsic memb...
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