Phosphatidic acid feeding increases muscle protein synthesis and select mTORC1 pathway signaling mediators in rodent skeletal muscle
نویسندگان
چکیده
Background Human and cell culture studies have demonstrated that phosphatidic acid (PA) can increase muscle mass and anabolic signaling, respectively. However, no in vivo evidence to date has examined whether PA can increase intramuscular anabolic signaling in vivo. The purpose of this study was to examine – a) if PA feeding acutely increases post-prandial muscle protein synthesis (MPS) and anabolic signaling markers; and b) if PA can enhance the post-prandial anabolic effects of whey protein concentrate (WPC).
منابع مشابه
mTORC 1 Signaling - Activated Increases in Muscle Protein Synthesis induced by leucine and Phosphatidic Acid : A Brief Review
The mammalian target of rapamycin (mTOR) is a signaling network that functions to regulate muscle protein synthesis (MPS). The effects of leucine and phosphatidic acid (PA) availability and growth factors such as insulin and insulin-like growth factor 1 (IGF-1) can up-regulate this signaling pathway and increase the initiation of protein translation necessary for MPS. mTORC1 is known to be tran...
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BACKGROUND Phosphatidic acid (PA) is a diacyl-glycerophospholipid that acts as a signaling molecule in numerous cellular processes. Recently, PA has been proposed to stimulate skeletal muscle protein accretion, but mechanistic studies are lacking. Furthermore, it is unknown whether co-ingesting PA with other leucine-containing ingredients can enhance intramuscular anabolic signaling mechanisms....
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