Reduced Tc-99m DMSA uptake in a patient with renal tubular acidosis: effect of acid-base imbalance.
نویسندگان
چکیده
Tc-99m dimercaptosuccinic acid (DMSA) is used as a renal cortical imaging agent to detect parenchymal abnormalities especially in children. Kidney uptake of DMSA provides an index for evaluation of a functional tubular mass, which depends on the renal blood flow and proximal tubular cell membrane transport function. We here report a boy with renal tubular acidosis, which has noticeably reduced uptake on his Tc-99m DMSA scintigraphy, despite a totally normal Tc-99m MAG-3 study. The case reported here clearly demonstrates a situation in which renal uptake of DMSA may be dissociated from a functional renal mass and the importance of acid-base balance which alters Tc-99m DMSA uptake.
منابع مشابه
Single photon emission-computed tomography (SPECT) for functional investigation of the proximal tubule in conscious mice.
Noninvasive analysis of renal function in conscious mice is necessary to optimize the use of mouse models. In this study, we evaluated whether single photon emission-computed tomography (SPECT) using specific radionuclear tracers can be used to analyze changes in renal proximal tubule functions. The tracers included (99m)TC- dimercaptosuccinic acid ((99m)Tc-DMSA), which is used for cortex imagi...
متن کاملPoor renal uptake of technetium-99m-DMSA and technetium-99m-MDP in a patient with Fanconi syndrome and near normal glomerular filtration rate.
We present a patient with Fanconi syndrome who demonstrated poor renal uptake of 99mTc-DMSA and high urinary concentration of the tracer. A 99mTc-DTPA scan was normal and the creatinine clearance only minimally decreased. These findings suggest that 99mTc-DMSA may be accumulated in the kidney by glomerular filtration and subsequent tubular reabsorption, with the nonabsorbed fraction appearing i...
متن کاملAssessment of the maximum uptake time of 99mTc-DMSA in renal scintigraphy in rat
Introduction:The optimal imaging time of a radionuclide scintigraphy is the time at which the organ of interest has the maximum uptake of the injected radionuclide. This study was performed to investigate the maximum uptake time of 99mTc-DMSA in rat renal scan. Methods: Renal scintigraphy was performed with 3 mCi of 99mTc-DMSA. Planar ima...
متن کاملImaging of medullary thyroid carcinoma with Tc-99m (V) DMSA [Persian]
Twenty-one patients with medullary thyroid carcinoma were studied prospectively with Tc-99m (V) DMSA after surgery. Pentavalent DMSA scintigram demonstrated abnormal uptake in 13 and equivocal uptake in 6 patients. Finally, seven patients with surgical or other imaging documentation were selected for this paper. Most of these patients were asymptomatic. Six patients had hypercalcitonemia ...
متن کاملComparative assessment of renal Tc-99m DMSA scan and renal sonography findings in complication of urinary tract infections [Persian]
Urinary tract infection (UTI) is a common disease in childhood specially in female. In this study 50 patients with stablished diagnosis of UTI were evaluated by both renal scan with Tc-99m DMSA and renal sonography. The study revealed that most urinary tract infections are in children, Female sex between 5-9 years of age. Therefore the most important complications (Renal scarring) are als...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Annals of nuclear medicine
دوره 16 7 شماره
صفحات -
تاریخ انتشار 2002