Characterizing the Inhibition of Katanin Using Tubulin Carboxy-Terminal Tail Constructs
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Deconstructing FAK function
Polyglutamylation makes the cut L acroix et al. report that the addition of long glutamate side chains to tubulin stimulates microtubule disassembly by the microtubule-severing protein spastin. The C-terminal tails of tubulin subunits can be modifi ed in different ways, which might alter the recruitment of molecular motors and other microtubule-binding proteins. A family of glutamylase enzymes ...
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contains unique, essential sequence elements, i.e., they Microtubules (MTs) are organized into distinct syshave completely redundant functions. tems essential for cell shape, movement, intracellular Glycylation is known to occur on glutamate residues transport, and division [1]. Electron crystallographic in the C terminus of and -tubulin in cells with axoanalyses [2] provide little information ...
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