Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions (review).
نویسندگان
چکیده
Metal ion homeostasis and heavy metal detoxification systems are regulated by certain genes associated with metal ion transport. Metallothionein (MT) and metal response element binding transcription factor 1 (MTF‑1) are important regulatory proteins involved in the mediation of intracellular metal ion balance. Differences in the zinc‑binding affinities of the zinc fingers of MTF‑1 and the α‑ and β‑domains of MT facilitate their regulation of Zn2+ concentration. Alterations in the intracellular concentration of Zn2+ influence the MTF‑1 zinc finger number, and MTF‑1 containing certain zinc finger numbers regulates the expression of corresponding target genes. The present review evaluates the association between zinc finger number in MTF‑1 protein, MTF‑1 target genes and the mechanism underlying MT regulation of the zinc finger number in MTF‑1.
منابع مشابه
Molecular Mechanism of the Metallothionein Gene Expression Mediated by Metal-Responsive Transcription Factor 1
Metal-responsive transcription factor 1 (MTF-1) is essential for activating transcription of the metallothionein genes in response to multiple species of heavy metals by binding to the metal-responsive element (MRE) located in the upstream region of the genes. In contrast, MTF-1 binding to the MRE in vitro is induced only by zinc ions, suggesting that MTF-1 acts as a zinc sensor protein. Althou...
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ورودعنوان ژورنال:
- Molecular medicine reports
دوره 11 3 شماره
صفحات -
تاریخ انتشار 2015