The use of self-assembled receptor layers in immunosensors

نویسندگان

  • R. P. H. Kooyman
  • D. J. van den Heuvel
  • J. W. Drijfhout
  • G. W. Welling
چکیده

We demonstrate that a self-assembled monolayer consisting of an alkylthiol coupled synthetic peptide adsorbed to a gold substrate results in a sensitive receptor surface for specific recognition of protein molecules. The affinity constant of this binding is comparable with that of an antibody-antigen reaction. Evidence is found that such a receptor surface is capable of reversible binding.

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تاریخ انتشار 2002