Cystic Fibrosis Related Diabetes
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چکیده
Diabetes mellitus and glucose intolerance are common in adolescent and adult patients with CF (Lanng et al, 1995; Moran et al, 1998). The prevalence of CF related diabetes (CFRD) increases with age (Moran et al, 1998) and in patients over 20 years of age may be as high as 53% (Lanng et al, 1995). CFRD occurs in up to 30% of individuals by the age of 25 and is invariably associated with pancreatic exocrine dysfunction (malabsorption). The average age of onset of CFRD is 18-21 years and it is slightly more common in females (Rosenecker et al, 1995; Yung & Hodson, 1999). Gestational diabetes occurs in between 10 and 30% of pregnancies in women with CF who are not diabetic beforehand (Gilljam et al, 2000; Odegaard et al, 2002; Barak et al, 2005; McMullen et al, 2006). The use of oral corticosteroids will increase the tendency to develop diabetes. CFRD is common among patients referred for lung transplantation and the prevalence of diabetes increases in the years after transplantation related in part to selection of immunosuppressive therapy (Hadjiliadis et al, 2005).
منابع مشابه
Microvascular complications in cystic fibrosis-related diabetes mellitus: a case report.
CONTEXT, The prevalence of cystic fibrosis-related diabetes mellitus is increasing and is associated with increased survival from cystic fibrosis. CASE REPORT, This study describes a case of the premature onset of disabling and widespread microvascular complications resulting from cystic fibrosis-related diabetes mellitus. Previously asymptomatic retinopathy was diagnosed on recognition of diab...
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