Mechanisms of Fatty Acid Effects on Sarcoplasmic Reticulum
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منابع مشابه
Mechanisms of fatty acid effects on sarcoplasmic reticulum. I. Calcium-fatty acid interaction.
To elucidate the mechanism for the previously reported increase in calcium sequestration by sarcoplasmic reticulum vesicles in the presence of palmitic acid, the ability of this fatty acid to bind calcium was investigated by dual wavelength spectrophotometry using the calcium indicator arsenazo III,, and by Millipore filtration using 45CaCl2. In the presence of 120 mM KCl, 1 mM MgCl2, 15 microM...
متن کاملMechanisms of Fatty Acid Effects on Sarcoplasmic Reticulum
The mechanism by which palmitic and oleic acids modify calcium sequestration by sarcoplasmic reticulum vesicles was investigated by examining the effects of these fatty acids on calcium -dependent ATPase activity, on the phosphoenzyme intermediates found during calcium sequestration reactions, and on passive membrane permeability to calcium. The calcium sequestered in the presence of these fatt...
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Low concentrations of fatty acids inhibited initial Ca uptake by sarcoplasmic reticulum vesicles, the extent of inhibition varying with chain length and unsaturation in a series of C14-C20 fatty acids. Oleic acid was a more potent inhibitor of initial Ca uptake than stearic acid at 25 degrees C, whereas at 5 degrees C there was less difference between the inhibitory effects of low concentration...
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Rat hearts pulse-labeled by perfusion in vitro with 9,10-oleic acid-H for 15 or 30 sec were shown to take up the fatty acid extensively. In hearts postperfused with unlabeled medium for 15 sec or more, 90% of the radioactivity was recovered in esterified lipids. The radioautographic reaction was localized initially over elements of the sarcoplasmic reticulum and mitochondria. After longer perio...
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Effects of lipid structure on the function of the Ca(2+)-ATPase of skeletal muscle of sarcoplasmic reticulum are reviewed. Binding of phospholipids to the ATPase shows little specificity. Phosphatidylcholines with short (C14) or long (C24) fatty acyl chains have marked effects on the activity of the ATPase, including a change in the stoichiometry of Ca binding. Low ATPase activity in gel phase ...
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