The influence of selective vitamin D receptor activator paricalcitol on cardiovascular system and cardiorenal protection
نویسندگان
چکیده
The ubiquitous distribution of vitamin D receptors in the human body is responsible for the pleiotropic effects of vitamin D-receptor activation. We discuss the possible beneficial effects of a selective activator of vitamin D receptor, paricalcitol, on the cardiovascular system in chronic heart failure patients and chronic kidney patients, in light of new trials. Paricalcitol should provide additional clinical benefits over the standard treatment for chronic kidney and heart failure, especially in cases of cardiorenal syndrome.
منابع مشابه
Effect of vitamin D analogues on acute cardiorenal syndrome: a laboratory rat model.
BACKGROUND Vitamin D has been shown to induce beneficial effects on cardiovascular and renal morbidity by regulating inflammation and tissue fibrosis. OBJECTIVES To evaluate the effect of vitamin D analogues on cardiac function and fibrosis in an animal model of cardiorenal syndrome. METHODS Unilateral nephrectomy was performed and myocardial infarction induced in rats. The rats were treate...
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