Biological Effects of Simulated Weightlessness on Bone Cells and Its Mechanism
نویسندگان
چکیده
Bone loss is a negative balance course especially occurred after long-term space flight for astronauts under weightlessness [1]. Bone remodeling is a dynamic process that requires the coordinated interaction of osteocytes, osteoblasts, and osteoclasts, collaborating in basic multicellular units (BMUs) [2]. Recently,osteocytes are believed to be the mechanosensors of bone, responding to mechanical stresses [3], but it is unclear exactly how osteocytes influence neighboring bone cells in weightlessness. Some kinds of groud-based simulated methods, such as clinostat culture and RCCS, have been used to simulate the effects of real weightlessness. Diamagnetic levitation technology is a novel approach for simulated weightlessness and has only recently been applied in biological research [4-7]. In this study, we investigated the effects of simulated weightlessness using diamagnetic levitation or the traditional method-3-D clinostat culture on proliferation, morphology, cytoskeleton architecture, cell cycle and apoptosis in
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