Copper-associated liver diseases.
نویسنده
چکیده
The liver is essential for copper metabolism. Copper metabolism is highly conserved between different species. This article provides the reader with an overview of copper storage disorders in humans and animals. Diagnosis and treatment of copper-associated hepatitis are described, and breed-specific characteristics of the disease are explained. A literature review references publications about the disease in companion animals.
منابع مشابه
Histological demonstration of copper and copper-associated protein in chronic liver diseases.
Liver copper concentrations in percutaneous biopsy specimens were measured by neutron activation analysis and compared with histological staining for copper by rubeanic acid and rhodanine, and with copper-associated protein stained by orcein. Liver copper concentrations were elevated in 31 of 35 biopsies from patients with primary biliary cirrhosis (PBC), and discrimination between normal and e...
متن کاملAnimal models of copper-associated liver disease
Recent advances in molecular biology have made possible the identification of genetic defects responsible for Wilson's disease, Indian childhood cirrhosis and copper toxicosis in Long Evans Cinnamon rats, toxic milk mice, and Bedlington terriers. The Wilson's disease gene is localized on human chromosome 13 and codes for ATP7B, a copper transporting P-type ATPase. A genetic defect similar to th...
متن کاملObservations on copper associated protein in childhood liver disease.
Hepatic copper concentrations were compared with staining grades of copper associated protein (CAP) and histochemical copper in liver sections from 44 patients (one fetus, one pre-term infant, four term infants, eight normal children, 16 children with various liver diseases, and 14 patients with intrahepatic cholestasis of childhood (IHCC)). A similar comparative study of hepatic copper concent...
متن کاملCopper-Associated Liver Disease: More Common than You Think
There is increasing recognition that inflammatory liver disease in dogs is associated with abnormal hepatic copper (Cu) concentrations. Abnormal hepatic Cu accumulation results as either a primary metabolic defect in Cu metabolism unique to some breeds or as a secondary event associated with chronic hepatic cholestasis resulting in a decrease in biliary excretion of hepatic Cu. Abnormal hepatic...
متن کاملDietary Management of Labrador Retrievers with Subclinical Hepatic Copper Accumulation
BACKGROUND Genetic and environmental factors, including dietary copper intake, contribute to the pathogenesis of copper-associated hepatitis in Labrador retrievers. Clinical disease is preceded by a subclinical phase in which copper accumulates in the liver. OBJECTIVE To investigate the effect of a low-copper, high-zinc diet on hepatic copper concentration in Labrador retrievers with increase...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Veterinary clinics of North America. Small animal practice
دوره 39 3 شماره
صفحات -
تاریخ انتشار 2009