Abstract: In Vivo Degradation of Hyaluronic Acid (HA)-Based Fillers by Exogenous Hyaluronidases

INTRODUCTION: A traditional orthognathic approach requires presurgical orthodontic treatment for an average of approximately 17 months, followed by surgery and postsurgical orthodontic treatment for approximately 6–12 months. Therefore, the total treatment time for the conventional orthognathic approach takes approximately 18–36 months. Because traditional orthognathic surgery requires 2–3 years to complete, it is a rarely adopted procedure. Therefore, shortening the total treatment time would be extremely beneficial for patients. Although presurgical orthodontic treatment has been approved as an inevitable process for stable orthognathic correction before surgery, recent advances in the application of mini-screws and presurgical simulational orthodontic management skills on a dental model show that it is possible to perform a surgery-first orthognathic approach without presurgical orthodontic treatment.