Vestibular Implantation and Longitudinal Electrical Stimulation of the Semicircular Canal 3 Afferents in Human Subjects

نویسندگان

  • James O. Phillips
  • Leo Ling
  • Kaibao Nie
  • Elyse Jameyson
  • Christopher M. Phillips
  • Amy L. Nowack
  • Justin S. Golub
  • Jay T. Rubinstein
چکیده

1 2 Vestibular Implantation and Longitudinal Electrical Stimulation of the Semicircular Canal 3 Afferents in Human Subjects 4 5 6 James O. Phillips 1,3,4 , Leo Ling 1,3 , Kaibao Nie 1,4 , Elyse Jameyson 1 , Christopher M. Phillips 1,3 , 7 Amy L. Nowack 1,3 , Justin S. Golub 1 , and Jay T. Rubinstein 1,2,3,4 8 9 10 Department of Otolaryngology-HNS 1 , Department of Bioengineering 2 , National Primate 11 Research Center 3 , Virginia Merrill Bloedel Hearing Research Center 4 12 13 University of Washington 14 15 16 Running heading: Vestibular implant in humans 17 18 Corresponding author: James O Phillips, Ph.D. 19 Virginia Merrill Bloedel Hearing Research Center 20 357923, CD176 CHDD Building 21 University of Washington 22 Seattle, Washington, 98195 23 Email: [email protected] 24 25 26 Keyword: vestibular, implant, human, Meniere’s 27 28 29 30 31 Articles in PresS. J Neurophysiol (February 4, 2015). doi:10.1152/jn.00171.2013

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Vestibular implantation and longitudinal electrical stimulation of the semicircular canal afferents in human subjects.

Animal experiments and limited data in humans suggest that electrical stimulation of the vestibular end organs could be used to treat loss of vestibular function. In this paper we demonstrate that canal-specific two-dimensionally (2D) measured eye velocities are elicited from intermittent brief 2 s biphasic pulse electrical stimulation in four human subjects implanted with a vestibular prosthes...

متن کامل

Electrical stimulation of semicircular canal afferents affects the perception of head orientation.

Patients with vestibular dysfunction have visual, perceptual, and postural deficits. While there is considerable evidence that a semicircular canal prosthesis that senses angular head velocity and stimulates canal ampullary nerves can improve vision by augmenting the vestibulo-ocular reflex, no information is available regarding the potential utility of a canal prosthesis to improve perceptual ...

متن کامل

Efferent vestibular system in the toadfish: action upon horizontal semicircular canal afferents.

The influence of the efferent vestibular system (EVS) upon the background discharge and response dynamics of horizontal semicircular canal afferents was examined in the toadfish. In one set of experiments the EVS was activated using a behavioral paradigm; in the second, electrical shocks were applied to the efferent vestibular nucleus in the brain stem. The afferent's background discharge and r...

متن کامل

1 Spatial and temporal properties of eye movements produced by 2 electrical stimulation of semicircular canal afferents 3 4

24 To investigate the characteristics of eye movements produced by electrical stimulation of 25 semicircular canal afferents, we studied the spatial and temporal features of eye movements 26 elicited by short-term lateral canal stimulation in two squirrel monkeys with plugged lateral 27 canals, with the head upright or statically tilted in the roll plane. The electrically-induced 28 vestibulo-o...

متن کامل

A Study on Physical Factors Stimulating the Semicircular Canals Receptors (Cupola)

SUMMARY Although sciences and techniques have been significantly developed, many patients are still suffering from diagnostic and therapeutic problems of vestibular system, specially vertigo. Perhaps, these problems are not solved yet mostly because the neurophysiology of vestibular system and the stimulation mechanisms of the receptors are not known. This difficulty, intum, causes some a mbig...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2015