Tau Peptides Offered by Bachem

P135: The Role of Amyloid Beta-Peptides and Tau Protein in Alzheimer\'s Disease

Alzheimer's desease is the most common age-related neurodegenerative disorder, and cognitive problems such as defects in learning and memory are of its symptoms.  Among the factors involved in the pathogenesis of the disease are biochemical disorders in protein production, oxidative stress, decreased acetylcholine secretion and inflammation of the brain tissue. Extra-neuronal accumulation ...

Non-ionic Detergents Offered by Bachem

Care and Handling of Amyloid Peptides

Bachem offers a broad range of amyloid peptides. Some of these peptides are notorious for their propensity to form scarcely soluble aggregates, which makes reconstitution diffi cult. As to help our customers, we have compiled a selection of literature references containing protocols for dissolving the peptides. We hope you will fi nd some information, which could be helpful for your experimenta...

Vip/pacap Peptides Offered by Bachem

Vasoactive intestinal polypeptide (VIP) and pituitary adenyl-ate cyclase activating polypeptide (PACAP) belong to a family of regulatory peptides which are widely expressed in the body. Their widespread distribution is correlated with their involvement in a large variety of biological activities. Both peptides display a remarkable amino acid sequence homology. They exert their biological effect...

Selection and Characterization of Tau Binding ᴅ-Enantiomeric Peptides with Potential for Therapy of Alzheimer Disease

A variety of neurodegenerative disorders, including Alzheimer disease (AD), are associated with neurofibrillary tangles composed of the tau protein, as well as toxic tau oligomers. Inhibitors of pathological tau aggregation, interrupting tau self-assembly, might be useful for the development of therapeutics. Employing mirror image phage display with a large peptide library (over 109 different p...