Colon Targeting Using pH Sensitive Materials

The oral route is the preferred route for drug delivery, among oral delivery Intestine and colon drug delivery have been used for molecules aimed at local treatment of colonic diseases such as Colon Cancer, Polyp, Colorectal, Crohn’s Disease, Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC) etc. and for delivery of molecules susceptible to enzymatic degradation such as peptides. There are various methods have been reported for colon targeting, among them use of pH sensitive polymers for coating and formulation of drug delivery system is most beneficial. The formulations of pH sensitive nanoparticles, hydrogel, microspheres, Polymeric Micelles are commonly reported for colon targeting. This review focuses on advancements of pH sensitive drug delivery system for colon targeting.