Maintenance of Thalamic Epileptiform Activity Depends on the Astrocytic 2 Glutamate - Glutamine Cycle 3
نویسندگان
چکیده
5 Dept. Neurology & Neurological Sciences, Stanford University, Stanford, CA 6 7 Running Head: Glutamate-Glutamine Cycle Supports Epileptic Activity 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 Corresponding Author 33 John R. Huguenard 34 [email protected] 35 36 Department of Neurology and Neurological Sciences 37 Room M030 Always Building 38 Stanford University School of Medicine 39 Stanford, CA, 94305-5122 40 Phone: 650-723-5522 41 Fax: 650-793-1080 42 Articles in PresS. J Neurophysiol (September 9, 2009). doi:10.1152/jn.00476.2009
منابع مشابه
Maintenance of thalamic epileptiform activity depends on the astrocytic glutamate-glutamine cycle.
The generation of prolonged neuronal activity depends on the maintenance of synaptic neurotransmitter pools. The astrocytic glutamate-glutamine cycle is a major mechanism for recycling the neurotransmitters GABA and glutamate. Here we tested the effect of disrupting the glutamate-glutamine cycle on two types of neuronal activity patterns in the thalamus: sleep-related spindles and epileptiform ...
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