Type 2 Diabetes Mellitus and Protein-Tyrosine Phosphatase 1B1
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چکیده
Diabetes is a common metabolic disease which characterized by hyperglycemia, mainly divided into type 1 diabetes mellitus and type 2 diabetes mellitus. Insulin-dependent type 1 diabetes mostly resulted from the damage of pancreatic β cells which makes the absolute lack of insulin; Type 2 diabetes, which insulin independent, the mainly initial factors are insulin resistance (IR) and the relative lack of insulin. Due to the modern diet and genetic factors, type 2 diabetes mellitus patients have increased in recent years. O’Rahilly and other experts predicted that the number of patients with type 2 diabetes mellitus will be more than 300 million by 2025, mainly in developing countries such as India [1-3]. Current treatments for type 2 diabetes mellitus are mainly dependent on insulin and some oral hypoglycemic agents. Long-term insulin injections to patients with a lot of pain and inconvenience, and the effect of oral hypoglycemic agents are often not satisfactory. Therefore, researchers are now looking for more safe and effective drugs and treatments.
منابع مشابه
Therapeutic Targets of Type 2 Diabetes: an Overview
Submit Manuscript | http://medcraveonline.com Abbreviations: T1D: Type 1 diabetes; T2D: Type 2 diabetes; NIDDM: Non-Insulin-Dependent Diabetes Mellitus; TNF-α: Tumor Necrosis Factor Alpha; IRS: Insulin Receptor and Substrates; RXR: Retinoid X-Receptor; PTP1B: Protein Tyrosine Phosphatase 1B; PTPs: Protein Tyrosine Phosphatases; GPR: G-Protein Coupled Receptor; LA: Lipoic Acid; NAC: N-Acetyl-l-C...
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