The subventricular zone neural progenitor cell hypothesis in glioblastoma: epiphany, Trojan Horse, or Cheshire fact?
نویسندگان
چکیده
The Subventricular Zone Neural Progenitor Cell Hypothesis in Glioblastoma: Epiphany, Trojan Horse, or Cheshire Fact? Iris C. Gibbs, MD,* Daphne Haas-Kogan, MD,y Stephanie Terezakis, MD,z and Brian D. Kavanagh, MD, MPHx Departments of Radiation Oncology, *Stanford University, Palo Alto, California; yUniversity of California, San Francisco; zJohns Hopkins University, Baltimore, Maryland; and xUniversity of Colorado, Aurora, Colorado
منابع مشابه
Isolation and Differentiation of Neural Stem/Progenitor Cells From Subventricular Zone of One Adult Rat
Introduction: In adult mammalian brain, neural stem cells are isolated from both the dentate gyrus and subventricular zone. This study aimed to isolate neural stem cells from adult rat subventricular zone and differentiate them into neurons and astrocytes. Methods: In this study, the whole brain was removed after full anesthesia and creating cervical dislocation. Under a microscope, subv...
متن کاملEnriched environment increases neural stem/progenitor cell proliferation and neurogenesis in the subventricular zone of stroke-lesioned adult rats.
BACKGROUND AND PURPOSE The subventricular zone in the adult brain is identified as an endogenous resource of neuronal precursors that can be recruited to adjacent lesioned areas. The hypothesis was tested that postischemic environmental enrichment might enhance subventricular zone cell genesis. METHODS A cortical infarct was induced in adult spontaneously hypertensive rats by ligating the mid...
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Human brain tumor stem cells have been enriched using antibodies against the surface protein CD133. An antibody recognizing CD133 also served to isolate normal neural stem cells from fetal human brain, suggesting a possible lineage relationship between normal neural and brain tumor stem cells. Whether CD133-positive brain tumor stem cells can be derived from CD133-positive neural stem or progen...
متن کاملMaking bigger brains-the evolution of neural-progenitor-cell division.
Relative brain size differs markedly between species. This variation might ultimately result from differences in the cell biology of neural progenitors, which might underlie their different proliferative potential. On the basis of the cell-biological properties of neural progenitors of animals of varying brain size and complexity (namely, Drosophila melanogaster, rodents and primates), we hypot...
متن کاملCD133 is not present on neurogenic astrocytes in the adult subventricular zone, but on embryonic neural stem cells, ependymal cells, and glioblastoma cells.
Human brain tumor stem cells have been enriched using antibodies against the surface protein CD133. An antibody recognizing CD133 also served to isolate normal neural stem cells from fetal human brain, suggesting a possible lineage relationship between normal neural and brain tumor stem cells. Whether CD133-positive brain tumor stem cells can be derived from CD133-positive neural stem or progen...
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ورودعنوان ژورنال:
- International journal of radiation oncology, biology, physics
دوره 86 4 شماره
صفحات -
تاریخ انتشار 2013