Erythropoietin: not just about erythropoiesis.
نویسندگان
چکیده
Ghezzi, P; Bernaudin, M; Bianchi, R; Blomgren, K; Brines, M; Campana, W; Cavaletti, G; Cerami, A; Chopp, M; Coleman, T; Digicaylioglu, M; Ehrenreich, H; Erbayraktar, S; Erbayraktar, Z; Gassmann, M; Genc, S; Gokmen, N; Grasso, G; Juul, S; Lipton, S A; Hand, C C; Latini, R; Lauria, G; Leist, M; Newton, S S; Petit, E; Probert, L; Sfacteria, A; Siren, A L; Talan, M; Thiemermann, C; Westenbrink, D; Yaqoob, M; Zhu, C
منابع مشابه
The human erythropoietin receptor gene rescues erythropoiesis and developmental defects in the erythropoietin receptor null mouse.
Erythropoietin and its receptor are required for definitive erythropoiesis and maturation of erythroid progenitor cells. Mice lacking the erythropoietin receptor exhibit severe anemia and die at about embryonic day 13.5. This phenotype can be rescued by the human erythropoietin receptor transgene. Animals expressing only the human erythropoietin receptor survived through adulthood with normal h...
متن کاملBrief report The human erythropoietin receptor gene rescues erythropoiesis and developmental defects in the erythropoietin receptor null mouse
Erythropoietin and its receptor are required for definitive erythropoiesis and maturation of erythroid progenitor cells. Mice lacking the erythropoietin receptor exhibit severe anemia and die at about embryonic day 13.5. This phenotype can be rescued by the human erythropoietin receptor transgene. Animals expressing only the human erythropoietin receptor survived through adulthood with normal h...
متن کاملErythropoiesis. Regulatory Mechanisms and Developmental Aspects
This volume contains the proceedings of a conference on erythropoiesis held at Tel Aviv University from July 27-29, 1970. Twenty-seven papers are listed under six headings: "Fetal and Neonatal Erythropoiesis," "Assay of Erythropoietin," "Androgens and Erythropoiesis," "Mechanism of Action of Erythropoietin," "Regulation of Erythropoiesis," and "Production of Erythropoietin: Renal and Extrarenal...
متن کاملErythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukin 3.
Erythropoietin (EPO) and its receptor (EPOR) are critical for definitive erythropoiesis, as mice lacking either gene product die during embryogenesis with severe anemia. Here we demonstrate that mice expressing just one functional allele of the EpoR have lower hematocrits and die more frequently than do wild-type littermates on anemia induction. Furthermore, EpoR(+/-) erythroid colony-forming u...
متن کاملErythropoietin production in virulent malaria.
Erythropoietin, the hormone responsible for stimulating erythrocyte production, was shown to increase significantly in the serum of mice during virulent malaria infection. Although erythropoiesis was enhanced, it did not keep pace with the rate of erythocyte destruction; hence all Plasmodium berghei-infected mice quickly succumbed to the deleterious consequences of severe uncompensated hemolyti...
متن کاملBone Marrow Response to Erythropoietin in Polycythemia
The regulation of erythropoiesis was control cultures. Erythropoietin was studied in patients with polycythemia ineffective in stimulating iron incorpovera and chronic granulocytic Ieukeration into heme in five patients with mia (CGL). An in vitro culture system polycythemia vera. The marrow rewas employed to determine the response to erythropoietin in vitro was sponse of bone marrow cells to e...
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ورودعنوان ژورنال:
- Lancet
دوره 375 9732 شماره
صفحات -
تاریخ انتشار 2010