Automate it: ligand-binding assay productivity in a discovery bioanalytical setting.

In multiple industries, including the biopharmaceutical industry, automation is synonymous with increased productivity. Environments with high-throughput needs commonly employ automation for efficiency. However, in a discovery bioanalytical ligand-binding assay laboratory setting where the focus is not necessarily on sample analysis throughput, but instead on assay development and characterization, is automation applicable? Can automation enhance productivity when tasks are more customized than routine? In this Perspective we review the different categories of automation with ligand-binding assays with these questions in mind. In considering whether automation technology has progressed far enough to result in a positive return in investment in the discovery setting, the resource investment required to operate in this space was contrasted with the gain in productivity. In our opinion, technology advancements in automated technology platforms, and especially personal automation, have allowed these categories to strike the right balance for investment in the discovery laboratory setting.