Modifying effects of 1,2-dichloropropane on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in male Syrian hamsters.

Inhibitory effect of 1α-hydroxyvitamin D3 on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in Syrian hamsters.

Sixty-three male 5-week-old Syrian hamsters received the carcinogen N-nitrosobis(2-oxopropyl)amine (BOP) s.c. in 5 weekly injections (the first, 70 mg/kg body, and the remaining, 20mg/kg each). The hamsters that received BOP were given intragastric administration of 0.2 ml of medium chain triglyceride (MCT) with or without 0.04 μg of 1α-hydroxyvitamin D3 [1α(OH)D3] through a feeding tube for 12...

Carcinogenic effect of N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine, a postulated proximate pancreatic carcinogen in Syrian hamsters.

N-Nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) proved to be a potent carcinogen in Syrian golden hamsters. The compound is an in vivo metabolite of N-nitrosobis(2-hydroxypropyl)amine, N-nitrosobis(2-oxopropyl)amine (BOP), and N-nitroso-2,6-dimethylmorpholine and a postulated proximate pancreatic carcinogen in hamsters. As with BOP, HPOP induced a higher incidence of pancreatic ductular ade...

Base-catalyzed decomposition of N-nitrosobis(2-oxopropyl)amine.

N-Nitrosobis(2-oxopropyl)amine, a potent carcinogen for the pancreas in Syrian hamsters, undergoes a facile, base-catalyzed, intramolecular aldol condensation to yield N-nitroso-5-hydroxy-5-methyl-3-piperidone. This cyclic nitrosamine then decomposes to yield 3-hydroxy-5-methylpyridine.

Non-enhanced MR imaging for the pancreas and pancreatic ductal adenocarcinomas induced by N-nitrosobis(2- oxopropyl)amine in Syrian golden hamsters

Tumorigenesis in the nasal olfactory region of Syrian golden hamsters as a result of di-n-propylnitrosamine and related compounds.

The morphology of neoplasms in the nasal olfactory region of the Syrian golden hamster observed after s.c. injections of di-/!-propylnitrosamine, ß-hydroxypropyl-H-propylnitrosamine, ß-oxopropyl-;i-propylnitrosamine, and methyl-/J-propylnitrosamine are described; all four compounds induced tumors. Neoplastia lesions were characterized by the proliferation of three often intermingled cell type...