Propagation-based Morphometry in an ex vivo mouse embryo atlas – assessment and validation
نویسندگان
چکیده
F. C. Norris, J. O. Cleary, M. Modat, A. N. Price, K. McCue, S. Beddow, P. J. Scambler, S. Ourselin, and M. F. Lythgoe Centre for Advanced Biomedical Imaging, Department of Medicine and UCL Institute of Child Health, University College London, London, United Kingdom, Centre for Mathematics and Physics in the Life Sciences and EXperimental Biology (CoMPLEX), University College London, London, United Kingdom, Department of Medical Physics and Bioengineering, University College London, London, England, United Kingdom, Centre for Medical Image Computing, University College London, London, United Kingdom, Molecular Medicine Unit, UCL Institute of Child Health, University College London, London, United Kingdom
منابع مشابه
Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome
We describe a fully automated pipeline for the morphometric phenotyping of mouse brains from μMRI data, and show its application to the Tc1 mouse model of Down syndrome, to identify new morphological phenotypes in the brain of this first transchromosomic animal carrying human chromosome 21. We incorporate an accessible approach for simultaneously scanning multiple ex vivo brains, requiring only...
متن کاملValidation of MRI-based 3D digital atlas registration with histological and autoradiographic volumes: An anatomofunctional transgenic mouse brain imaging study
Murine models are commonly used in neuroscience to improve our knowledge of disease processes and to test drug effects. To accurately study neuroanatomy and brain function in small animals, histological staining and ex vivo autoradiography remain the gold standards to date. These analyses are classically performed by manually tracing regions of interest, which is time-consuming. For this reason...
متن کاملDev125872 3583..3591
After more than a century of research, the mouse remains the goldstandard model system, for it recapitulates human development and disease and is quickly and highly tractable to genetic manipulations. Fundamental to the power and success of using amousemodel is the ability to stage embryonic mouse development accurately. Past staging systems were limited by the technologies of the day, such tha...
متن کاملIn vitro versus In vivo: Development-, Apoptosis-, and Implantation-Related Gene Expression in Mouse Blastocyst
Background: While mammalian embryos can adapt to their environments, their sensitivity overshadows their adaptability in suboptimal in vitro conditions. Therefore, the environment in which the gametes are fertilized or to which the embryo is exposed can greatly affect the quality of the embryo and consequently its implantation potential. Objectives:</stro...
متن کاملImaging lung microstructure in mice with hyperpolarized 3He diffusion MRI.
Quantitative measurement of lung microstructure is of great significance in assessment of pulmonary disease, particularly in the earliest stages. The technique for MRI-based 3He lung morphometry was previously developed and validated for human lungs, and was recently extended to ex vivo mouse lungs. The technique yields accurate, quantitative information about the microstructure and geometry of...
متن کامل