PIP2—the Master Key
نویسندگان
چکیده
The function of inwardly rectifying K+ (Kir) channels is highly diverse and therefore is tightly regulated by various environmental factors. In their article in this issue of Neuron, Rapedius et al. recognize a conserved structural mechanism for Kir channels gating by both pH and PIP2. In light of these findings and accumulated knowledge, PIP2 is suggested to have a common coregulatory role in the gating of Kir channels by all their soluble modulators.
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ورودعنوان ژورنال:
- Neuron
دوره 55 شماره
صفحات -
تاریخ انتشار 2007