Suppression of histone deacetylation in vivo and in vitro by sodium butyrate.
نویسندگان
چکیده
In HeLa cells which have been exposed to 5 mM sodium butyrate for 21 h, the level of histone acetylation is greatly increased as compared to control cells (Riggs, M.G., Whittaker, R.G., Neumann, J.R., and Ingram, V.R. (1977) Nature 268, 462-464). Our experiments indicate that the increase in the relative amounts of multiacetylated forms of histones H4 and H3 following butyrate treatment is the result of an inhibition of histone deacetylase activity.
منابع مشابه
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ورودعنوان ژورنال:
- The Journal of biological chemistry
دوره 253 10 شماره
صفحات -
تاریخ انتشار 1978