Modulation of Hypoxia in Solid Tumor Microenvironment with MnO<sub>2</sub> Nanoparticles to Enhance Photodynamic Therapy
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چکیده
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 5490 wileyonlinelibrary.com recognized as one of the characteristic hallmarks in solid tumors with insuffi cient oxygen supply, directly contributing to the malignant properties of cancers. It is known that hypoxia plays essential roles in tumor angiogenesis and cancer metastasis. [ 4–6 ] Moreover, hypoxia would also lead to resistance to medical therapies, [ 7–13 ]
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