Dementia diagnostic criteria in Down syndrome.

نویسندگان

  • Rory Sheehan
  • Amanda Sinai
  • Nick Bass
  • Pippa Blatchford
  • Ingrid Bohnen
  • Simon Bonell
  • Ken Courtenay
  • Angela Hassiotis
  • Therese Markar
  • Jane McCarthy
  • Kamalika Mukherji
  • Asim Naeem
  • Dimitrios Paschos
  • Natalia Perez-Achiaga
  • Vijaya Sharma
  • David Thomas
  • Zuzana Walker
  • Andre Strydom
چکیده

OBJECTIVE Dementia is a common clinical presentation among older adults with Down syndrome. The presentation of dementia in Down syndrome differs compared with typical Alzheimer's disease. The performance of manualised dementia criteria in the International Classification of Diseases (ICD)-10 and Diagnostic and Statistical Manual of Mental Disorders-IV-Text Revision (DSM-IV-TR) is uncertain in this population.We aimed to determine the concurrent validity and reliability of clinicians' diagnoses of dementia against ICD-10 and DSM-IV-TR diagnoses. Validity of clinical diagnoses were also explored by establishing the stability of diagnoses over time. METHODS We used clinical data from memory assessments of 85 people with Down syndrome, of whom 64 (75.3%) had a diagnosis of dementia. The cases of dementia were presented to expert raters who rated the case as dementia or no dementia using ICD-10 and DSM-IV-TR criteria and their own clinical judgement. RESULTS We found that clinician's judgement corresponded best with clinically diagnosed cases of dementia, identifying 84.4% cases of clinically diagnosed dementia at the time of diagnosis. ICD-10 criteria identified 70.3% cases, and DSM-IV-TR criteria identified 56.3% cases at the time of clinically diagnosed dementia. Over time, the proportion of cases meeting ICD-10 or DSM-IV-TR diagnoses increased, suggesting that experienced clinicians used their clinical knowledge of dementia presentation in Down syndrome to diagnose the disorder at an earlier stage than would have been possible had they relied on the classic description contained in the diagnostic systems. CONCLUSIONS Clinical diagnosis of dementia in Down syndrome is valid and reliable and can be used as the standard against which new criteria such as the DSM-5 are measured.

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عنوان ژورنال:
  • International journal of geriatric psychiatry

دوره 30 8  شماره 

صفحات  -

تاریخ انتشار 2015