Quinine and Pregnancy
نویسنده
چکیده
Sih.?Regarding Dr. Subra Row's opinion of using " quinine in pregnancy," I beg to state that in my experience "quinine" rarely does harm to a pregnant women suffering from malarial fever. Recently I treated two cases of advanced pregnancy (one seven months' pregnancy and another nine months' pregnancy), suffering from malarial fever (both with high fever, enlarged spleen and liver). I treated them with quinine ten grains daily for four days. In both cases it did not induce labour at all. _ I administered quinine in malarial fever in pregnant state in several cases but with no bad result. I tried to induce^ labour in three malarial cases with pregnancy with quinine, but it proved ineffective.
منابع مشابه
Clinical Pharmacology of the Antimalarial Quinine in Children
Quinine is the best studied drug for treating severe malaria in very young children. Quinine may be administered in pregnancy and, at therapeutic doses, malformations have not been reported. Some strains of quinine from Southeast Asia and South America have become resistant. Quinine is the treatment of choice for the drug-resistant severe Plasmodium falciparum. The antimalarial mechanism of qui...
متن کاملQuinine in Pregnancy
The fact that quinine is used to overcome uterine inertia in weak women, and as an ecbolic is always prescribed during labour, if there is no obstruction, is mainly responsible for the general impression that its use should be avoided during pregnancy as far as possible. Clinical experience, however, warrants no such fear about the administration of quinine during pregnancy. Hare, in his Practi...
متن کاملArtemisinin-Based Combination Therapy Versus Quinine or Other Combinations for Treatment of Uncomplicated Plasmodium falciparum Malaria in the Second and Third Trimester of Pregnancy: A Systematic Review and Meta-Analysis
The World Health Organization recommends artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated falciparum malaria in the second and third trimesters of pregnancy. We conducted a meta-analysis to compare efficacy, safety and tolerability of ACTs versus quinine and other non-ACT antimalarials. The median PCR-adjusted failure rate by days 28 to 63 in the non-ACT group w...
متن کاملPopulation pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda
OBJECTIVES Oral quinine is used for the treatment of uncomplicated malaria during pregnancy, but few pharmacokinetic data are available for this population. Previous studies have reported a substantial effect of malaria on the pharmacokinetics of quinine resulting from increased α-1-acid glycoprotein levels and decreased cytochrome P450 3A4 activity. The aim of this study was to investigate the...
متن کاملQuinine and Pregnancy
Sir,?In reply to this question, l-ecently asked in the 7. M. G., I have to state that I have given quinine, both by the mouth, hypodermic and intramuscular injections, for malaria in pregnant patients without any harmful result. The following case, however, is both interesting and peculiar. An unmarried lady could not take more than five grains of quinine on a sea voyage without producing a flo...
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