Effect of Carica papaya leaf formulation on Hematology and Serology of normal rat

Thrombocytopenia is a disorder in which there is a thrombocyte count of less than 150×103/μL. Thrombocytopenia is life threatening in many diseases particularly in dengue which is an escalating problem in the world. There was an outbreak of dengue in 2011 in Lahore, Pakistan and it was public opinion that Carica papaya leaf extract helps in recovery of platelet count. The aim of present study was to investigate the effect of Carica papaya leaf extract on blood chemistry specifically thrombocyte count of rats. Local syrup of papaya leaf extract was used for experimentation. Six animals were used for experiment, 3 as control and 3 experimental. The dose given to experimental animals was 0.5 ml of papaya leaf extract for 7 consecutive days which were at fasting for 4 hours before dose administration. There was a significant increase in mean platelet count, Mean Cell Haemoglobin (MCH) and Mean Corpuscular Volume (MCV) (p<0.05) of the treated animals as compared to control after seven days treatment with Carica papaya (CP) leaf formulations. The results described the need for isolation and identification of the C. papaya substances responsible for the release and/or production of thrombocytes. From the experimentation it can be concluded that C. papaya leaf extract is associated with rapid increase of platelet count.