Vitreous and Aqueous Penetration of Orally Administered Moxifloxacin in Humans
نویسندگان
چکیده
Results: The mean±SD moxifloxacin concentrations in plasma (n=15), vitreous (n=13), and aqueous (n=13) samples were 3.56±1.31 μg/mL, 1.34±0.66 μg/mL, and 1.58±0.80 μg/mL, respectively. Mean±SD sampling times after oral administration of the second moxifloxacin tablet for plasma, vitreous, and aqueous were 2.94±0.81 hours, 3.77±0.92 hours, and 3.71±0.89 hours, respectively. The percentages of plasma moxifloxacin concentration in the vitreous and aqueous were 37.6% and 44.3%, respectively. Minimal inhibitory concentrations against 90% levels were exceeded against a wide spectrum of gram-positive and gram-negative pathogens in the vitreous and aqueous.
منابع مشابه
Human intraocular penetration pharmacokinetics of moxifloxacin 0.5% via topical and collagen shield routes of administration.
PURPOSE To determine penetration of moxifloxacin 0.5% into human aqueous and vitreous via topical and collagen shield routes of administration. METHODS Moxifloxacin 0.5% was administered prior to vitrectomy surgery through one of three routes: topical drops every 2 hours for 3 days, versus topical drops every 6 hours for 3 days, versus delivery using a 24-hour dissolvable cross-linked corneal...
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