The micrograft concept for wound healing: strategies and applications.

نویسندگان

  • Atanu Biswas
  • Manish Bharara
  • Craig Hurst
  • David G Armstrong
  • Horacio Rilo
چکیده

The standard of care for wound coverage is to use an autologous skin graft. However, large or chronic wounds become an exceptionally challenging problem especially when donor sites are limited. It is important that the clinician be aware of various treatment modalities for wound care and incorporate those methods appropriately in the proper clinical context. This report reviews an alternative to traditional meshed skin grafting for wound coverage: micrografting. The physiological concept of micrografting, along with historical context, and the evolution of the technique are discussed, as well as studies needed for micrograft characterization and future applications of the technique.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Acceleration Mechanisms of Skin Wound Healing by Autologous Micrograft in Mice

A micrograft technique, which minces tissue into micro-fragments >50 μm, has been recently developed. However, its pathophysiological mechanisms in wound healing are unclear yet. We thus performed a wound healing study using normal mice. A humanized mouse model of a skin wound with a splint was used. After total skin excision, tissue micro-fragments obtained by the Rigenera protocol were infuse...

متن کامل

Development of antimicrobial chitosan based nanofiber dressings for wound healing applications

Objective(s): Chitosan based composite fine fibers were successfully produced via a centrifugal spinning technology. This study evaluates the ability of the composites to function as scaffolds for cell growth while maintaining an antibacterial activity. Materials and methods: Two sets of chitosan fiber composites were prepared, one filled with anti-microbial silver nanoparticles and another on...

متن کامل

Review Paper: Application of Hair Follicle Bulge Stem Cells in Wound Healing

Despite the significant advances in regenerative medicine, wound healing has remained a challenging clinical problem. Skin is the largest human organ with many vital functions; therefore, any damage to its normal structure should be treated as soon as possible. Easy access to skin stem cells has created a lot of excitement in therapeutic applications. “Cell therapy” is considered a novel method...

متن کامل

Fate of the Dermal Component of Micrografts in Full-Thickness Wounds

Dear Sir, The most widely used skin graft in the treatment of full-thickness wounds, caused by major burns or trauma, is split-thickness skin grafts (STSGs). 1-3 In an attempt to increase the expansion ratio of the STSGs, our laboratory has previously shown that autologous minced skin grafting accelerates reepitheliazation. 4-7 The micrografts (0.8 mm × 0.8 mm) are generated by controlled minci...

متن کامل

Modern wound dressings and their application

Introdution: Wound healing is a complex and dynamic process, which requires to be prepared a suitable environment to promote healing process. Wound dressing is one of the most important external factors affecting the wound healing process. With the advancement in technology, more than 1000 types of modern wound dressings have been developed. Wound dressings are either based on natural materials...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of diabetes science and technology

دوره 4 4  شماره 

صفحات  -

تاریخ انتشار 2010