C–H Functionalization
نویسنده
چکیده
C–H Functionalization has the potential to become a paradigmshifting strategy for organic synthesis. Over the last decade, the field has experienced explosive growth and a large variety of new C–H functionalization methodologies have been developed. In particular, regioselective functionalization of sp2 C–H bonds has become a broadly flexible approach for the synthesis of complex aromatic carbocycles and heterocycles. In several instances the substrates have a natural preference for functionalization at specific C–H bonds. Alternatively, selective functionalization is achieved by using a directing group to orient the catalyst in a defined position. These types of synthetic strategies are already having a significant impact on the streamlined synthesis of important compounds for the pharmaceutical industry and materials science.
منابع مشابه
Collective Approach to Advancing C–H Functionalization
C-H functionalization is a very active research field that has attracted the interest of scientists from many disciplines. This Outlook describes the collaborative efforts within the NSF CCI Center for Selective C-H Functionalization (CCHF) to develop catalyst-controlled selective methods to enhance the synthetic potential of C-H functionalization.
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The functionalization of C-H bonds has created new approaches to preparing organic molecules by enabling new strategic "disconnections" during the planning of a synthetic route. Such functionalizations also have created the ability to derivatize complex molecules by modifying one or more of the many C-H bonds. For these reasons, researchers are developing new types of functionalization reaction...
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