CC Chemokine Receptor 3 Human Eotaxin by Affecting Its Interaction Potency , But Not the Anti - HIV Activity of Down - Regulates the Eosinophil Chemotactic CD 26 / Dipeptidyl - Peptidase IV
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منابع مشابه
Cleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78beta into a most efficient monocyte attractant and CCR1 agonist.
Chemokines are proinflammatory cytokines that play a role in leukocyte migration and activation. Recent reports showed that RANTES (regulated on activation normal T-cell expressed and secreted chemokine), eotaxin, macrophage-derived chemokine (MDC), and stromal cell-derived factor-1 (SDF-1) are NH(2)-terminally truncated by the lymphocyte surface glycoprotein and protease CD26/dipeptidyl peptid...
متن کاملCleavage by CD26/dipeptidyl peptidase IV converts the chemokine LD78b into a most efficient monocyte attractant and CCR1 agonist
Chemokines are proinflammatory cytokines that play a role in leukocyte migration and activation. Recent reports showed that RANTES (regulated on activation normal T-cell expressed and secreted chemokine), eotaxin, macrophagederived chemokine (MDC), and stromal cell–derived factor-1 (SDF-1) are NH2terminally truncated by the lymphocyte surface glycoprotein and protease CD26/ dipeptidyl peptidase...
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The serine protease CD26/dipeptidyl-peptidase IV (CD26/DPP IV) and chemokines are known key players in immunological processes. Surprisingly, CD26/DPP IV not only removed the expected Gly1-Pro2 dipeptide from the NH2 terminus of macrophage-derived chemokine (MDC) but subsequently also the Tyr3-Gly4 dipeptide, generating MDC(5-69). This second cleavage after a Gly residue demonstrated that the s...
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