Clickable peptide nucleic acids (cPNA) with tunable affinity.
نویسندگان
چکیده
Peptide nucleic acids (PNAs) are functional analogues of natural oligonucleotides. Herein, we report the synthesis of PNAs bearing a triazole in lieu of the amide bond assembled using a "click" cycloaddition, their hybridization properties as well as the DNA-templated coupling of the azide and alkyne PNA fragments.
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 30 شماره
صفحات -
تاریخ انتشار 2010