Chew 1..10
نویسندگان
چکیده
work opens a new avenue for the design of a neuroprosthesis for bladder control after spinal cord injury. prevented the rat bladder from emptying inappropriately, and bladder contraction was initiated when desired. This improving the resolution. Using this sensory information and by manipulating stimulation characteristics, the authors that accurately encoded bladder filling. The device had multiple microchannels for concurrent recording, greatly . implanted fine-diameter nerves (''rootlets'') into insulated microchannels, recording action potential firing et al Chew nerves, but produce poor signal quality and provide little indication of bladder filling. Through nerve microdissection, record robust neuronal activity from peripheral nerves in vivo. Typically, cuff electrodes are used to record from whole emptying can be artificially stimulated on demand by electrically modulating nerve firing. It is traditionally difficult to accurately record bladder filling from sensory nerves after spinal cord injury in rat. Using this information, bladder . design a ''closed-loop'' electronic device that can et al leading to inappropriate emptying. In a new study, Chew this is cumbersome and leads to urological complications including unsolicited episodes of bladder contraction, Currently, only limited treatment options are available, with most of the patients receiving catheterization. However, Injury to the spinal cord typically results in loss of conscious bladder emptying and the sensation of fullness. Getting to the Root of Bladder Control
منابع مشابه
Bacterial chemotaxis signaling complexes: formation of a CheA/CheW complex enhances autophosphorylation and affinity for CheY.
We have demonstrated that a complex of the proteins CheA (CheAL and CheAS) and CheW can be isolated and constitutes a functional unit that responds to the signaling state of the chemoreceptors. The autophosphorylation rate of CheAL is much greater when CheAL and CheAS are complexed with CheW. Moreover, the presence of mutant chemoreceptors that cause cells to tumble increases this rate. At wild...
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The C-terminal P5 domain of the histidine kinase CheA is essential for coupling CheA autophosphorylation activity to chemoreceptor control through a binding interaction with the CheW protein. To locate P5 determinants critical for CheW binding and chemoreceptor control, we surveyed cysteine replacements at 39 residues predicted to be at or near the P5 surface in Escherichia coli CheA. Two-third...
متن کاملDisruption of chemoreceptor signalling arrays by high levels of CheW, the receptor-kinase coupling protein.
During chemotactic signalling by Escherichia coli, the small cytoplasmic CheW protein couples the histidine kinase CheA to chemoreceptor control. Although essential for assembly and operation of receptor signalling complexes, CheW in stoichiometric excess disrupts chemotactic behaviour. To explore the mechanism of the CheW excess effect, we measured the physiological consequences of high cellul...
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Homology models of the E. coli and T. maritima chemotaxis protein CheW were constructed to assess the quality of structural predictions and their applicability in chemotaxis research: i) a model of E. coli CheW was constructed using the T. maritima CheW NMR structure as a template, and ii) a model of T. maritima CheW was constructed using the E. coli CheW NMR structure as a template. The confor...
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Background and Aims: Studies show that sucrose containing chewing gums are cariogenic. The aim of this study was to evaluate the effect of two commercial chewing gums with and without sucrose on dental plaque accumulation compared with the control group. Materials and Methods: In this clinical study, plaque accumulation during three 7-day periods (with two weeks interval) was recorded (Sillnes...
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