Simultaneous PET and MR Imaging with a Newly Developed 3TMR-BrainPET Scanner
نویسندگان
چکیده
A prototype of a new bimodal scanner was installed in our laboratory. This scanner combines magnetic resonance imaging (MRI) and positron emission tomography (PET) for brain studies. As the PET detector is located within the bore of the MRI scanner, simultaneous measurements become possible. The MR-component consists of a commercial 3T MRI scanner MAGNETOM Tim-Trio, whereas the PET detector BrainPET has been newly developed. The readout electronics of the PET are based on avalanche photodiodes (APDs) which can be applied in the magnetic field. The inner diameter of the PET ring, which consists of 32 cassettes, is 36 cm so that an MRI head coil can be inserted into this ring. First tests were carried out to analyse the countrate behaviour and the image resolution. To assess the image quality of simultaneous MR-PET, phantom studies were performed. The image resolution in the centre was between 2.1 and 2.5mm in x,y and z directions. First MR-PET studies showed no visible artefacts of the MR image and FDG-PET images provided high-resolution delineation of the cortex.
منابع مشابه
Simultaneous trimodal PET-MR-EEG imaging: Do EEG caps generate artefacts in PET images?
Trimodal simultaneous acquisition of positron emission tomography (PET), magnetic resonance imaging (MRI), and electroencephalography (EEG) has become feasible due to the development of hybrid PET-MR scanners. To capture the temporal dynamics of neuronal activation on a millisecond-by-millisecond basis, an EEG system is appended to the quantitative high resolution PET-MR imaging modality alread...
متن کاملComparison of cerebral blood flow acquired by simultaneous [15O]water positron emission tomography and arterial spin labeling magnetic resonance imaging
Until recently, no direct comparison between [(15)O]water positron emission tomography (PET) and arterial spin labeling (ASL) for measuring cerebral blood flow (CBF) was possible. With the introduction of integrated, hybrid magnetic resonance (MR)-PET scanners, such a comparison becomes feasible. This study presents results of CBF measurements recorded simultaneously with [(15)O]water and ASL. ...
متن کاملEffects of Magnetic Fields of up to 9.4 T on Resolution and Contrast of PET Images as Measured with an MR-BrainPET
Simultaneous, hybrid MR-PET is expected to improve PET image resolution in the plane perpendicular to the static magnetic field of the scanner. Previous papers have reported this either by simulation or experiment with simple sources and detector arrangements. Here, we extend those studies using a realistic brain phantom in a recently installed MR-PET system comprising a 9.4 T MRI-scanner and a...
متن کاملAdapting MR-BrainPET scans for comparison with conventional PET: experiences with dynamic FET-PET in brain tumours
Institute of Neuroscience and Medicine (INM-3,-4,-5), Forschungszentrum Juelich, Juelich, Germany Imaging results from subsequent measurements (preclinical 3T MR-BrainPET, HR+) are compared. O-(2-[F]fluoroethyl)-L-tyrosine (FET) may exhibit non-uniform tracer uptake in gliomas. The aim was to analyse and adapt the physical properties of the scanners and study variations of biological tumour vol...
متن کاملHigh-resolution, quantitative 3D PET image reconstruction for the Siemens hybrid 3T MR/BrainPET scanner using the PET reconstruction software toolkit (PRESTO)
Institute of Neuroscience and Medicine-4, Forschungszentrum Juelich, Germany The Siemens 3T MR-BrainPET scanner allows us to simultaneously acquire high-resolution MR and PET images thus giving a strong asset for studies of the human brain. Meanwhile, the system is routinely used for MR-PET studies with a variety of radiotracers, e.g. F-FDG, F-FET, C-Raclopride, C-Flumazenil, O-Water. Based on ...
متن کامل