GENETIC POLYMORPHISM OF GLUTATHION S-TRANSFERASE P1 (GSTP1) Ile105Val AND SUSCEPTIBILITY TO ATHEROGENESIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
نویسندگان
چکیده
1 Department of Human Genetics and Prenatal Diagnostics, Zvezdara University Medical Center, Belgrade, Serbia Dedinje Cardiovascular Institute , University of Belgrade, Belgrade, Serbia Geriatrics Department, Zvezdara University Medical Center, Belgrade, Serbia European Center for Peace and Development Established by United Nations University of Peace, Belgrade, Serbia; Institute of Human Genetics, School of Dentistry, University of Belgrade, Belgrade, Serbia 6 School of Medicine, University of Belgrade, Belgrade, Serbia
منابع مشابه
Evaluation of glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism and susceptibility to type 2 diabetes mellitus, a meta-analysis
It is well established that type 2 diabetes mellitus (T2DM) is associated with oxidative stress and glutathione S-transferases (GSTs) protect cells against oxidative stress. The missense substitution Ile105Val (rs1695) of the glutathione S-transferase P1 (GSTP1, OMIM: 134660) results from an A/G base substitution at nucleotide 313. Many studies have evaluated the correlation between the rs1695 ...
متن کاملAssociations of the glutathione S-transferase P1 Ile105Val genetic polymorphism with gynecological cancer susceptibility: a meta-analysis
The association between the glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism and gynecological cancer susceptibility has been evaluated in many studies. However, the results remain controversial. Thus, this meta-analysis, based on 10 published case-control studies, was designed to clarify the association of the GSTP1 Ile105Val polymorphism with gynecological cancer risk. Our results ...
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BACKGROUND AND AIMS Diabetic neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM). Genetic susceptibility and oxidative stress may play a role in the appearance of T2DM and diabetic neuropathy. We investigated the relation between polymorphism in genes related to oxidative stress such as GSTM1, GSTT1, and GSTP1 and the presence of T2DM and diabetic neuropathy (DN). METHODS...
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Glutathione-S-transferase P1 (GSTP1) is a critical enzyme of the phase II detoxification pathway. One of the common functional polymorphisms of GSTP1 is A→G at nucleotide 313, which results in an amino acid substitution (Ile105Val) at the substrate binding site of GSTP1 and reduces catalytic activity of GSTP1. To investigate the GSTP1 Ile105Val genotype frequency in prostate cancer cases i...
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