Variants of interleukin-16 associated with gastric cancer risk.

The Role of Interleukin 1β Gene Polymorphism in Gastric Cancer in North-eastern Iran

Background and Objective: Host genetic factors such as cytokine gene polymorphisms as well as Helicobacter pylori (H. pylori) infection have been found to be associated with gastric cancer risk . Interleukin 1 is a pro-inflammatory cytokine involved in H. pylori-induced gastric inflammation. Therefore, w...

Study of cyp2E1 gene RsaI/PstI polymorphisms in patients with gastric cancer in north of Iran

Background: North of Iran is amongst high incidence rate areas of gastric carcinoma where environmental carcinogenic compounds especially agricultural pesticides are massively used. Cytochrome P450 2E1 (CYP2E1) enzyme metabolically activates a large number of low molecular mass xenobiotics. The polymorphic nature of cyp2E1 gene control elements is associated with interindividual differences...

افزایش خطر ابتلا به سرطان معده با چند شکلی VNTR ژن SIRT3

Background and purpose: Gastric cancer is the most common cancer associated with high mortality worldwide. One of the genes that is down-regulated in gastric cancer, is the SIRT3 that encodes the histone deacetylase enzyme. There is a variable number tandem repeat (VNTR) polymorphism in the intron 5 of SIRT3 gene and evidence shows that expression of SIRT3 gene increases by increase in the numb...

Association of interleukin-1 gene polymorphism with risk of gastric and colorectal cancers in an Iranian population

Interleukin-8 polymorphisms are not associated with gastric cancer risk in a Polish population.

Inflammation seems to play a critical role in the development of many types of cancer, including gastric, colorectal, and bladder cancers (1-6). The presence of chronic inflammation has been well described in gastric cancer, the fourth most common cancer diagnosis and second most common cause of cancer death worldwide (4, 7-9). Genetic variants of several pathways critical for the inflammatory ...