Green Tea Leaf Extract as a Herbal Castrative Agent on Morphological and Functional Changes in Adult Male Gonads of Albino Rats

Experiment has been done to show the effect of Green Tea Leaf Extract (GTLE) on male reproductive system and also justify its effect to use GTLE as a castrative agent. Green Tea Leaf Extract was prepared according to the method used in Wei. H. et al (1999). The extract was given to the two different experimental animal groups with two different doses. After applying the doses in 26 consecutive days, it was found that the weight of the testis and epididymis was markedly decreased in highly treated group. The sperm count and its motility was also reduced drastically. But the alteration of enzymes like Serum Glutamate Oxaloacetate Transaminase (SGOT) and Serum Glutamate Pyruvate Transaminase (SGPT) was not significant. Result of this study showed that GTLE, relatively at high dose has its castrative activity on male reproductive system. Histological examination showed inhibition of spermatogenesis as evidence by disintegration of seminiferous tubules of testis.